The Ultimate Longevity Supplement Tier List (S-Tier to F-Tier)
Published by the Longevity Formulas Team | Reading Time: 12 minutes
When it comes to anti-aging supplements, not all are created equal. After years of research, countless customer feedback, and staying on top of the latest scientific studies, we've created the definitive tier list to help you prioritise your longevity stack.
We've ranked supplements based on scientific evidence, bioavailability, safety profile, and real-world results from our customers.
How Our Tier System Works:
- S-Tier: Essential. These are the foundation of any serious longevity protocol
- A-Tier: Excellent additions with strong scientific backing
- B-Tier: Good supplements worth considering for specific goals
- C-Tier: Modest benefits, situational use
- D-Tier: Overhyped with limited evidence
- F-Tier: Avoid these—waste of money or potentially harmful
S-TIER: The Non-Negotiables
1. NMN (Nicotinamide Mononucleotide)
Why it's S-Tier: The gold standard for NAD+ restoration. By middle age, your NAD+ levels have plummeted by 50%, affecting everything from energy production to DNA repair. NMN is the most direct pathway to restore these crucial levels.
The Science: Multiple human clinical trials show NMN effectively raises NAD+ levels, improves insulin sensitivity, and enhances mitochondrial function. Unlike other NAD+ precursors, NMN requires just one conversion step.
What to Look For:
- Minimum 500mg daily dose
- Delayed-release capsules for optimal absorption
- Third-party tested for purity
At Longevity Formulas, our NMN 500mg uses pharmaceutical-grade delayed-release technology and provides a full 2-month supply.
Best For: Everyone over 30, especially if you're experiencing fatigue, slower recovery, or want to prevent age-related decline.
2. Complete NMN Complex Formulations
Why it's S-Tier: While standalone NMN is excellent, combining it with synergistic compounds amplifies the benefits and addresses multiple aging pathways simultaneously.
The Science: Research shows that compounds like resveratrol activate sirtuins (longevity genes), TMG prevents methyl group depletion from NMN supplementation, and quercetin provides powerful anti-inflammatory effects.
Key Components to Look For:
- NMN (500mg minimum)
- TMG to support methylation
- Trans-resveratrol for sirtuin activation
- Quercetin for inflammation control
- Pterostilbene for enhanced bioavailability
Our NMN Complex contains all these ingredients in optimal ratios, saving you from buying multiple separate supplements.
Best For: Those wanting maximum anti-aging benefits from a single product.
3. Magnesium Glycinate
Why it's S-Tier: Magnesium is involved in over 300 enzymatic reactions, yet most people are deficient. It's crucial for energy production, sleep quality, and cellular repair—all fundamental to longevity.
The Science: Magnesium deficiency accelerates aging and increases inflammation. Glycinate form offers superior absorption compared to cheaper alternatives like magnesium oxide.
Optimal Dosage: 200-400mg before bed
Best For: Everyone. This is one supplement where there are virtually no downsides and massive benefits.
A-TIER: Excellent Additions
4. Omega-3 (EPA/DHA)
Why it's A-Tier: Essential for brain health, cardiovascular function, and reducing systemic inflammation. Your body can't produce these fatty acids, making supplementation crucial.
The Science: Decades of research link higher omega-3 levels to longer telomeres, better cognitive function, and reduced risk of age-related diseases.
What to Look For:
- Minimum 1000mg combined EPA/DHA
- Triglyceride form (better absorption)
- Third-party tested for heavy metals
Best For: Everyone, particularly those with limited fish intake.
5. Vitamin D3 + K2
Why it's A-Tier: Vitamin D deficiency is epidemic in the UK, especially during winter months. The addition of K2 ensures calcium goes to bones rather than arteries.
The Science: Optimal vitamin D levels are associated with better immune function, bone health, and potentially longer lifespan. K2 works synergistically to prevent arterial calcification.
Optimal Dosage: 2000-4000 IU D3 with 100-200mcg K2
Best For: UK residents (due to limited sun exposure) and anyone over 40.
6. Curcumin (with Piperine)
Why it's A-Tier: One of nature's most powerful anti-inflammatory compounds. Chronic inflammation is a hallmark of aging, making curcumin a valuable addition.
The Science: Studies show curcumin can reduce inflammatory markers, support joint health, and may have neuroprotective effects.
Critical Point: Must include piperine (black pepper extract) for bioavailability—otherwise, you're wasting your money.
Best For: Those with inflammatory conditions or anyone wanting comprehensive anti-aging support.
B-TIER: Worth Considering
7. CoQ10 (Ubiquinol Form)
Why it's B-Tier: Essential for mitochondrial energy production, but your body produces it naturally until around age 40. After that, supplementation becomes beneficial.
The Science: CoQ10 levels decline with age, affecting cellular energy. Supplementation can improve exercise performance and cardiovascular health.
Important: Choose ubiquinol form for better absorption, especially if you're over 40.
Best For: People over 40, those taking statins, or anyone with cardiovascular concerns.
8. Alpha Lipoic Acid
Why it's B-Tier: Known as the "universal antioxidant" because it works in both water and fat-soluble environments. Good for metabolic health and blood sugar control.
The Science: Can improve insulin sensitivity and protect against oxidative damage. However, benefits are more modest compared to S-Tier supplements.
Best For: Those with metabolic concerns or wanting additional antioxidant support.
9. Berberine
Why it's B-Tier: Excellent for blood sugar control and metabolic health. Sometimes called "nature's metformin" for its glucose-lowering effects.
The Science: Multiple studies show berberine can improve insulin sensitivity and support healthy blood sugar levels.
Best For: Those with prediabetes, metabolic syndrome, or blood sugar concerns.
C-TIER: Modest Benefits
10. Standalone Resveratrol
Why it's C-Tier: While resveratrol has impressive studies in isolation, bioavailability is poor without enhancement. Better taken as part of a complex.
The Science: Activates longevity genes (sirtuins) but absorption issues limit real-world benefits when taken alone.
Better Alternative: Get resveratrol as part of a comprehensive formula like our NMN Complex.
11. Green Tea Extract (EGCG)
Why it's C-Tier: Solid antioxidant with some metabolic benefits, but effects are relatively mild compared to higher-tier options.
Best For: Those wanting gentle metabolic support or additional antioxidants.
12. Probiotics
Why it's C-Tier: Important for gut health, which impacts overall aging, but effects vary dramatically between individuals and strains.
The Science: Gut health influences inflammation and immune function, but finding the right probiotic for you can be challenging.
D-TIER: Overhyped
13. Standalone Nicotinamide Riboside (NR)
Why it's D-Tier: While NR can boost NAD+, it requires more conversion steps than NMN and is typically much more expensive for comparable benefits.
The Issue: Marketing often oversells benefits while charging premium prices. NMN offers better value and more direct NAD+ support.
14. Low-Quality Collagen Products
Why it's D-Tier: Many cheap collagen supplements use poor-quality sources or inadequate dosing. However, high-quality marine collagen with proper bioactive peptides can support joint health and gut lining integrity.
The Key Difference: Look for hydrolysed marine collagen with specific peptide profiles and third-party testing. Avoid generic "collagen" without clear sourcing or potency information.
15. Most "Proprietary Blends"
Why it's D-Tier: When companies won't tell you exact dosages, it's usually because the amounts are too low to be effective.
Red Flag: If you can't see individual ingredient amounts, be very suspicious.
F-TIER: Avoid These
16. Cheap, Unverified Supplements
Why it's F-Tier: Whether it's £5 NMN from unknown sources or "miracle" anti-aging pills from social media ads, these often contain little to no active ingredients.
The Danger: At best, you're wasting money. At worst, you're consuming contaminated or mislabeled products.
17. Mega-Dose Antioxidant Cocktails
Why it's F-Tier: Your body needs some oxidative stress for proper adaptation. Mega-dosing antioxidants can actually interfere with beneficial processes like exercise adaptation.
The Science: More isn't always better. Hormesis (beneficial stress) is crucial for longevity.
18. Anti-Aging "Fountain of Youth" Pills
Why it's F-Tier: If it sounds too good to be true, it probably is. Legitimate longevity research focuses on specific pathways, not miracle cures.
How to Build Your Optimal Stack
Start Here (Essential Foundation):
- NMN Complex or standalone NMN
- Magnesium Glycinate
- Vitamin D3 + K2
- High-quality Omega-3
Add These Next (If Budget Allows):
- Curcumin with Piperine
- CoQ10 (if over 40)
Consider These Last:
- Alpha Lipoic Acid
- Berberine (if metabolic concerns)
Key Principles for Smart Supplementation
Quality Over Quantity
It's better to take fewer high-quality supplements than many cheap ones. We always recommend third-party tested products with transparent labelling.
Consistency Trumps Perfection
Taking your supplements consistently at 80% of the "optimal" dose is better than taking the perfect dose sporadically.
Listen to Your Body
Start with one supplement at a time to gauge your response. Everyone's biochemistry is different.
Don't Neglect the Basics
No supplement can overcome poor sleep, chronic stress, or a terrible diet. Address fundamentals first.
What This Means for Your Longevity Journey
The supplement industry loves to overcomplicate things, but effective anti-aging doesn't require 20+ different pills. Focus on the S-Tier foundations, add A-Tier supplements based on your specific needs, and ignore the marketing hype around lower-tier options.
Remember, longevity isn't just about supplements—they're tools to support a healthy lifestyle, not replace it. Combine smart supplementation with regular exercise, quality sleep, stress management, and a nutrient-dense diet for the best results.
At Longevity Formulas, we're committed to cutting through the noise and providing you with evidence-based products that actually work. Every supplement in our range has earned its place through rigorous research and real-world results.
Ready to start your longevity journey? Explore our complete range of scientifically-backed NMN supplements, or read our comprehensive NAD+ supplement guide to learn more about the science behind healthy aging.
Have questions about building your optimal stack? Our team is here to help—contact us for personalised guidance based on your specific goals and circumstances.