NMN and fibromyalgia: has it been studied?

NMN has not been studied in people with fibromyalgia. When I searched on 10 November 2026, PubMed listed no study of NMN and fibromyalgia, in people or in animals, and ClinicalTrials.gov listed no trial testing it. No food supplement sold in Great Britain may claim to treat or relieve fibromyalgia, and NMN has no authorised health claims at all.

What I found when I searched the research

Where I looked	What I searched for	Result
PubMed	Nicotinamide mononucleotide and fibromyalgia	No studies
PubMed	NMN and fibromyalgia	No studies
PubMed	Nicotinamide riboside (a related compound) and fibromyalgia	No studies
ClinicalTrials.gov	Fibromyalgia trials using nicotinamide compounds	No trial testing NMN

You can run the same search yourself on PubMed. I will update this page if a study is published. Our tracker of human NMN trials lists every trial we know of and who took part. Most enrolled healthy adults, and none enrolled people with fibromyalgia.

How to judge what other sites say about NMN and fibromyalgia

A lot of pages online say NMN helps with fibromyalgia. Before you trust one, check these four things.

• Open the studies it cites. Check whether each one tested NMN, in people, and in people with fibromyalgia. Many pages cite research in mice, in cells or on a different compound such as NR, then write as if it applied to you.
• Check whether the link is direct or loose. If it takes several steps of reasoning to get from the paper to the claim, the claim is a theory, not a finding.
• Look at who wrote it. If the page sells NMN and promises a result, UK law says it should not be making that claim. Our guide to red flags in NMN marketing explains why.
• Ask whether it reads as if AI wrote it. Generic headings, the same phrases repeated, no named author, no date and no specific sources often mean the page was generated to rank in search, not written by someone who read the research. Treat that as a red flag.

UK food law does not allow any supplement to claim to treat, cure or prevent a disease, so an NMN page that names fibromyalgia as something it helps is making a claim it is not allowed to make.

What "no published research" means

It does not prove that NMN does nothing for people with fibromyalgia. It means nobody has tested it, so there is no result either way, and nobody, including us, can promise you anything. Personal accounts are worth listening to, and a lot of research starts with them. But one person's experience cannot show what caused a change, which is why trials exist.

If you decide to try NMN, tell your GP, change one thing at a time so you know what made any difference, and keep a note of how you personally get on.

What fibromyalgia is

The NHS describes fibromyalgia as a long-term condition that causes pain all over the body. Other symptoms can include extreme tiredness, muscle stiffness, difficulty sleeping, problems with memory and concentration, often called fibro fog, and headaches. The cause is not fully understood. The NHS fibromyalgia page covers the symptoms and how it is diagnosed.

What the NHS and NICE recommend for fibromyalgia

There is no cure, so treatment aims to ease symptoms. The NHS lists exercise programmes, talking therapies such as cognitive behavioural therapy, and some medicines, including certain antidepressants.

In England, NICE guideline NG193 covers chronic primary pain, which includes fibromyalgia. It recommends supervised exercise programmes, some psychological therapies, acupuncture in some cases and some antidepressants. It advises against starting several common painkillers for this kind of pain. Your GP works from this guideline, and you can read it on the NICE website.

If you have fibromyalgia and are thinking about NMN

• Speak to your GP or pharmacist first. This matters most if you take amitriptyline, duloxetine, pregabalin or gabapentin. None of them has been tested alongside NMN. Our page on NMN and medication sets out what is known for each common medicine, and the "Can I take NMN with" checker covers other supplements.
• Do not change your prescribed treatment because you have started a supplement.
• The safety data comes from other people. The trials that recorded side effects mostly enrolled healthy adults. Our guide to NMN side effects shows what they found.
• Know where NMN stands legally. It is a novel food under assessment by the Food Standards Agency. Our page on UK NMN rules explains what that means.