Sirtuin Supplements

Sirtuins are proteins that regulate cellular ageing, DNA repair, and metabolism. They require NAD+ to function and become less active as we age. These supplements support sirtuin activity through NAD+ boosting or direct activation.

What Sirtuins Do

  • Repair DNA damage
  • Regulate cellular energy production
  • Control inflammation
  • Influence metabolism

Research shows sirtuin activation extends lifespan in organisms from yeast to mice. Human studies demonstrate metabolic benefits, though longevity effects remain unproven.

Our Sirtuin-Supporting Supplements

NMN (Nicotinamide Mononucleotide)

Converts to NAD+, the cofactor sirtuins need to function. Clinical trials show 250-900mg daily raises NAD+ levels significantly within 4 weeks.

Best for: Direct NAD+ support with strongest human evidence
Dosing: 250-500mg daily

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NMN Complex

Combines NMN (300mg) with resveratrol (150mg), TMG (500mg), and quercetin (100mg) for comprehensive sirtuin support plus methylation and senolytic benefits.

Best for: All-in-one sirtuin and cellular health support
Customer feedback: Better results than NMN alone

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Trans-Resveratrol

Directly activates SIRT1, mimicking some molecular effects of caloric restriction. Strong mechanistic evidence, though human trials show mixed results.

Best for: Direct SIRT1 activation
Dosing: 150-300mg daily

Alpha Lipoic Acid

Activates AMPK, which works alongside sirtuins in metabolic regulation. Also supports mitochondrial function (a SIRT3 target).

Best for: Metabolic health and indirect sirtuin support
Dosing: 600mg R-alpha lipoic acid

Vitamin D3/K2

Supports gene expression pathways that overlap with sirtuin regulation. Less direct than other options but supports cellular environment.

Best for: Foundation supplement alongside targeted sirtuin activators

Which Product Is Right for You?

New to sirtuin support? Start with NMN. Strongest human evidence, clearest mechanism.

Want comprehensive support? Choose NMN Complex for NAD+ boosting plus direct SIRT1 activation.

Focused on metabolic health? Add Alpha Lipoic Acid for AMPK activation.

Prefer established compounds? Resveratrol has decades of research, though human results vary.

What to Expect

Timeline based on research:

  • Week 4: NAD+ levels peak with consistent NMN use
  • Week 8-12: Metabolic improvements appear in trials

Realistic benefits:

  • Improved metabolic markers
  • Better exercise recovery
  • Enhanced cellular stress resistance
  • Gradual energy improvements

Not realistic:

  • Dramatic age reversal
  • Overnight transformations
  • Proven lifespan extension (no human trials exist)

User feedback shows best results when combining supplements with exercise, time-restricted eating, and stress management.

Quality Standards

All products manufactured in GMP-certified UK facilities with:

  • Batch-specific certificates of analysis
  • Purity testing
  • Pharmaceutical-grade ingredients
  • No unnecessary fillers

View Our Certificates of Analysis →

The Evidence

Strong support: NAD+ declines with age; sirtuins require NAD+; NMN raises NAD+ in humans.

Promising but unproven: Sirtuin activation extends lifespan in yeast, worms, flies, and shows metabolic benefits in mice. Human longevity effects unknown.

Our approach: Support well-established cellular pathways with measurable metabolic benefits, while being honest that human longevity extension remains theoretical.

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Written by Mathew Stuckey, Founder, Longevity Formulas. Last reviewed: 31 December 2025.